Biofilm eradication and prevention : a pharmaceutical approach to medical device infections

• Tác giả: Tamilvanan Shunmugaperumal
• Ngôn ngữ: eng
• Ký hiệu phân loại: 610.284 Medicine and health
• Thông tin xuất bản: Hoboken, N.J. : Wiley, 2010
• Mô tả vật lý: xiii, 423 p. : , ill. ; , 25 cm.
• Bộ sưu tập: Khoa học ứng dụng
• ID: 121439
• Chủ đề: 1. Biofilms; 2. Medical instruments and apparatus--Microbiology; 3. Medical instruments and apparatus--Sterilization; 5. Anti-Infective Agents--therapeutic use; 6. Drug Carriers--therapeutic use; 7. Prostheses and Implants--microbiology; 8. Prosthesis-Related Infections--prevention & control

Includes bibliographical references and index.

Tóm tắt

"Biofilm Eradication and Preventions presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation"--Provided by publisher.