The Pangenome [electronic resource] : Diversity, Dynamics and Evolution of Genomes

• Tác giả: Duccio Medini, Tettelin Hervé.
• Ngôn ngữ: ger
• ISBN-13: 978-3030382810
• Ký hiệu phân loại: 579.135 +Genetics
• Thông tin xuất bản: Cham : Springer International Publishing : Imprint: Springer, 2020
• Mô tả vật lý: XIV, 307 p. 47 illus., 43 illus. in color. , online resource.
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 168780
• Chủ đề: 1. Biomathematics; 2. Evolutionary biology; 3. Genetics; 4. Human genetics; 5. Microbial ecology; 6. Microbial genetics; 7. Microbial genomics; 8. Microbial Genetics and Genomics; 9. Evolutionary Biology; 10. Genetics and Genomics; 11. Genetics and Population Dynamics; 12. Human Genetics; 13. Microbial Ecology

Tóm tắt

This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book's respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.