Brain Tumors and the Lynch Syndrome

• Tác giả: Annette Gylling, Päivi Peltomäki
• Ngôn ngữ: eng
• ISBN-13: 978-9533076461
• Thông tin xuất bản: InTechOpen, 2011
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 189967
• Chủ đề: 1. Science: general issues

Tóm tắt

Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal cancers (Lynch & de la Chapelle, 2003).