Colorectal cancer remains a major health issue for many developed regions around the world. The good news is that early detection has significantly improved overall survival rates and continues to do so. A number of prevention strategies contribute to this positive trend, and today a patient who undergoes a colonoscopy for screening purposes stands a much better chance of being effectively surveyed for prevention of colorectal cancer. Patients can rely increasingly on the improved datasets and technical advances that are being made in screening approaches and skills. With continued progress, particularly in the partnership between clinicians and computer scientists, the future for colorectal cancer surveillance looks increasingly positive for the development of improved tools and methods.