As suggested by the title of this Special Issue, liquid chromatography-mass spectrometry plays a pivotal role in the field of proteomics. Indeed, the research and review articles
published in the Issue clearly evidence how the data produced by this sophisticated methodology may promote impressive advancements in this area. From among the topics discussed in the Issue, a few point to the development of
new procedures for the
optimization of the experimental conditions that should be applied
for the identification of proteins present in complex mixtures.
Other applications
described in these articles show
the huge potential of
these strategies in the protein profiling of organs and
range from
to the study of post-translational tissue modifications to the investigation of the molecular mechanisms behind human disorders and the identification of potential biomarkers of these diseases.