Histaminergic neurotransmission as a gateway for the effects of the fat sensing molecule Oleoylethanolamide : Focus on cognition and stress-reactivity

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Tác giả: Alessia Costa

Ngôn ngữ: eng

ISBN-13: 978-8864539942

Ký hiệu phân loại: 615 Pharmacology and therapeutics

Thông tin xuất bản: Florence : Firenze University Press, 2019

Mô tả vật lý: 1 electronic resource (124 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 241337

The histaminergic system is a pleiotropic system that commands general states of metabolism and consciousness, including learning and memorizing both pleasurable and aversive events. Brain histamine mediates the central effects of a signal molecule produced in the intestine, namely oleoylethanolamide (OEA). OEA is released by the enterocytes in response to high fat intake and reduces eating, by indirectly activating a subpopulation of histaminergic neurons. In her thesis, she explored other potential interactions between these two systems in the pursuit of unexplored neuronal mechanisms that may shed light on the mode of action of psychoactive agents and possibly lead to the development of new drugs.
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