This book includes 15 articles published in the Special Issue "Theoretical Computer Science and Discrete Mathematics" of Symmetry (ISSN 2073-8994). This Special Issue is devoted to original and significant contributions to theoretical computer science and discrete mathematics. The aim was to bring together research papers linking different areas of discrete mathematics and theoretical computer science, as well as applications of discrete mathematics to other areas of science and technology. The Special Issue covers topics in discrete mathematics including (but not limited to) graph theory, cryptography, numerical semigroups, discrete optimization, algorithms, and complexity.