Benchmarking blockchain-based gene-drug interaction data sharing methods [electronic resource] : A case study from the iDASH 2019 secure genome analysis competition blockchain track

• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.0475 Diseases
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. National Nuclear Security Administration ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2021
• Mô tả vật lý: Size: Article No. 104559 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259645
• Chủ đề: 1. 60 applied life sciences; 2. Blockchain distributed ledger technology; 3. Data sharing; 4. Gene-drug interaction; 5. Pharmacogenetics; 6. Smart contract

Tóm tắt

Blockchain distributed ledger technology is just starting to be adopted in genomics and healthcare applications. Despite its increased prevalence in biomedical research applications, skepticism regarding the practicality of blockchain technology for real-world problems is still strong and there are few implementations beyond proof-of-concept. We focus on benchmarking blockchain strategies applied to distributed methods for sharing records of gene-drug interactions. We expect this type of sharing will expedite personalized medicine. We generated gene-drug interaction test datasets using the Clinical Pharmacogenetics Implementation Consortium (CPIC) resource. We developed three blockchain-based methods to share patient records on gene-drug interactions: Query Index, Index Everything, and Dual-Scenario Indexing. We achieved a runtime of about 60 s for importing 4,000 gene-drug interaction records from four sites, and about 0.5 s for a data retrieval query. Our results demonstrated that it is feasible to leverage blockchain as a new platform to share data among institutions.