Thiourea-Derived Chelating Ligands and Their Organometallic Compounds [electronic resource] : Investigations into Their Anticancer Activity

• Ngôn ngữ: eng
• Ký hiệu phân loại: 664.7 Grains, other seeds, their derived products
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2020
• Mô tả vật lý: Size: Article No. 3661 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259825
• Chủ đề: 1. 60 applied life sciences; 2. Bioorganometallics; 3. Cancer chemotherapeutics; 4. Hydrogen bonds; 5. Molecular structures; 6. Thione ligands; 7. X-ray fluorescence microscopy

Tóm tắt

 Thiones have been investigated as ligands in metal complexes with catalytic and biological activity. We report the synthesis, characterization, and biological evaluation of a series of MII/III complexes of the general formulae [M<
 sup>
 II<
 /sup>
 (cym)(L)Cl]X (cym = ?<
 sup>
 6<
 /sup>
 -p-cymene) or [M<
 sup>
 III<
 /sup>
 (Cp*)(L)Cl]X (Cp* = ?<
 sup>
 5<
 /sup>
 -pentamethylcyclopentadienyl), where X = Cl<
 sup>
 -<
 /sup>
  or PF<
 sub>
 6<
 /sub>
 <
 sup>
 -<
 /sup>
 , and L represents heterocyclic derivatives of thiourea. The thiones feature a benzyl-triazolyl pendant and they act as bidentate ligands via N,S-coordination to the metal centers. Several derivatives have been investigated by single-crystal X-ray diffraction analysis. NMR investigations showed a counterion-dependent shift of several protons due to the interaction with the counterions. These NMR investigations were complemented with X-ray diffraction analysis data and the effects of different counterions on the secondary coordination sphere were also investigated by DFT calculations. In biological studies, the Ir benzimidazole derivative was found to accumulate in the cytoplasm and it was the most cytotoxic derivative investigated.