Relevance of biomarkers across different neurodegenerative diseases [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 612.8 Nervous system Sensory functions
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2020
• Mô tả vật lý: Size: Article No. 56 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259870
• Chủ đề: 1. 60 applied life sciences; 2. Alzheimer?s disease; 3. Amyloid; 4. Biomarkers; 5. Cerebrospinal fluid; 6. Et al; 7. Magnetic resonance imaging; 8. Neurodegenerative diseases; 9. Neurofilament light chain; 10. Positron emission tomography; 11. Tau

Tóm tắt

The panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and increasing use, appropriate implementation and interpretation are paramount. Various biomarkers feature nuanced differences in strengths, limitations, and biases that must be considered when investigating disease etiology and clinical utility. For example, neuropathological investigations of Alzheimer?s disease pathogenesis can fall in disagreement with conclusions reached by biomarker-based investigations. Considering the varied strengths, limitations, and biases of different research methodologies and approaches may help harmonize disciplines within the neurodegenerative disease field.