Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 572.9 Biochemistry
• Thông tin xuất bản: Bethesda, Md. : Oak Ridge, Tenn. : National Institutes of Health (U.S.) ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2019
• Mô tả vật lý: Size: p. 210-218 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259921
• Chủ đề: 1. 60 applied life sciences; 2. Fitness; 3. Hiv-1; 4. Infection; 5. Mutation; 6. Transmittedfounder virus

Tóm tắt

Viral fitness plays an important role in HIV-1 evolution, transmission and pathogenesis. However, how mutations accumulated during early infection affect viral fitness has not been well studied. We generated paired infectious molecular clones (IMCs) for transmitted/founder (T/F) and 6-month (6-mo) viruses post infection from 10 infected individuals to investigate the impact of accumulated mutations on viral fitness by comparing 6-mo viruses to their cognate T/F viruses. We found that all ten 6-mo viruses were less fit than their cognate T/F viruses. Moreover, the fitness losses of the 6-mo viruses correlated with the decrease in viral loads from the peak of viremia. Furthermore, these results show that the mutations accumulated during half a year post infection collectively reduce viral fitness and thereby contribute to lowering viral loads.