Bioinspired Peptoid Nanotubes for Targeted Tumor Cell Imaging and Chemo-Photodynamic Therapy [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.99 Tumors and miscellaneous communicable diseases
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2019
• Mô tả vật lý: Size: Article No. 1902485 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259969
• Chủ đề: 1. 60 applied life sciences; 2. 77 nanoscience and nanotechnology; 3. Chemo?photodynamic therapy; 4. Peptoids nanotube; 5. Singlet oxygen; 6. Targeted drug delivery

Tóm tắt

Substantial progress has been made in applying nanotubes in biomedical applications such as bioimaging and drug delivery due to their unique architecture, characterized by very large internal surface areas and high aspect ratios. Yet, the biomedical applications of organic nanotubes, especially for those assembled from sequence-defined molecules, are very uncommon. In our work, the synthesis of two new peptoid nanotubes (PepTs1 and PepTs2) is reported by using sequence-defined and ligand-tagged peptoids as building blocks. These nanotubes are highly robust due to sharing a similar structure to those of nontagged ones, and offer great potential to hold guest molecules for biomedical applications. The findings indicate that peptoid nanotubes loaded with doxorubicin drugs are promising candidates for targeted tumor cell imaging and chemo-photodynamic therapy.