Ovarian cancer (OvCa) is the fifth leading cause of cancer deaths in women and remains the most deadly gynecological cancer. The disease places a debilitating burden on the US population, in terms of mortality, morbidity, individual suffering and loss of productivity for all women with OvCa. National expenditures for OvCa care were estimated at $5.12B in 2010. The high fatality of OvCa is attributed to the fact that most patients are diagnosed at a late stage, with 63% diagnosed at Stage III or later. Effective early-stage diagnosis is challenging because there are no approved screening procedures for the general population, which has led to OvCa being termed1 the ?silent killer?. We have previously shown that public awareness and knowledge about OvCa is poor among the general population. It has also been reported that ovarian masses have often been misdiagnosed, although there was some association of pre-diagnostic symptoms with OvCa and with OvCa diagnostic stages. The motivation for the current study was to examine the association of diagnostic patterns (determined by the responses from ?frontline? clinicians, specifically primary care physicians (PCPs) and emergency room (ER) doctors, together with follow-up by specialists), with OvCa stages.