Whole genome analysis of a schistosomiasis-transmitting freshwater snail [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 575.3 Specific parts of and physiological systems in plants
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2017
• Mô tả vật lý: Size: Article No. 15451 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260545
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. Science & technology - other topics

Tóm tắt

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization?s goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.