A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 610 Medicine and health
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2015
• Mô tả vật lý: Size: Article No. 9194 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261206
• Chủ đề: 1. 60 applied life sciences

Tóm tắt

 New anticancer agents and modalities for their use are of great interest. Recent studies have demonstrated the presence of anti-cancer properties in salen derivatives. We found that an iron salen derivative, i.e., [Fe(salen)]<
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 O, displays ferromagnetic order above room temperature and shows spontaneous field-dependent magnetization and hysteresis. Understanding of this magnetic property is provided by first-principles calculations based on structures obtained by X-ray crystallography. [Fe(salen)]<
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 2<
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 O exhibited potent anti-cancer properties against various cancer cell types and was readily attracted by even moderate-strength permanent magnets in vitro. We demonstrated that the delivery of [Fe(salen)]<
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 2<
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 O to melanoma tissues transplanted into the tails of mice using a permanent magnet leads to a robust decrease in tumor size. The local accumulation of [Fe(salen)]<
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 2<
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 O was visualized by MRI. Thus, [Fe(salen)]<
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 O acted as an anti-cancer and MRI contrast compound that has a pharmacological effect that is delivered in a controlled manner, suggesting new strategies for anti-cancer drug development.