Red fluorescent zinc oxide nanoparticle [electronic resource] : A novel platform for cancer targeting

• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.5 Nanotechnology
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2015
• Mô tả vật lý: Size: p. 3373-3381 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261239
• Chủ đề: 1. 36 materials science; 2. 37 inorganic, organic, physical, and analytical chemistry; 3. 60 applied life sciences; 4. 77 nanoscience and nanotechnology; 5. Angiogenesis; 6. Cd105; 7. Drug delivery; 8. Imaging; 9. Positron emission tomography; 10. Zinc oxide

Tóm tắt

 Multifunctional zinc oxide (ZnO) nanoparticles (NPs) with well-integrated multimodality imaging capacities have generated increasing research interest in the past decade. However, limited progress has been made in developing ZnO NP-based multimodality tumor-imaging agents. Here we developed novel red fluorescent ZnO NPs and described the successful conjugation of <
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 64<
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 Cu (t<
 sub>
 1/2 <
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 = 12.7 h) and TRC105, a chimeric monoclonal antibody against CD105, to these ZnO NPs via well-developed surface engineering procedures. The produced dual-modality ZnO NPs were readily applicable for positron emission tomography (PET) imaging and fluorescence imaging of the tumor vasculature. Their pharmacokinetics and tumor-targeting efficacy/specificity in mice bearing murine breast 4T1 tumor were thoroughly investigated. ZnO NPs with dual-modality imaging properties can serve as an attractive candidate for future cancer theranostics.