Engineering of thermotolerant Bacillus coagulans for production of D(-)-lactic acid [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 507.1 Education, research, related topics
• Thông tin xuất bản: Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2014
• Mô tả vật lý: Medium: ED : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261355
• Chủ đề: 1. 54 environmental sciences; 2. 59 basic biological sciences; 3. 60 applied life sciences

Tóm tắt

Genetically modified microorganisms having the ability to produce D(-)-lactic acid at temperatures between 30.degree. C. and 55.degree. C. are provided. In various embodiments, the microorganisms may have the chromosomal lactate dehydrogenase (ldh) gene and/or the chromosomal acetolactate synthase (alsS) gene inactivated. Exemplary microorganisms for use in the disclosed methods are Bacillus spp., such as Bacillus coagulans.