Effect of the amyloid ? hairpin's structure on the handedness of helices formed by its aggregates [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.7 Dogs
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2013
• Mô tả vật lý: Size: p. 2649-2655 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261487
• Chủ đề: 1. 60 applied life sciences; 2. Alzheimer's; 3. Amyloid; 4. Protein structure

Tóm tắt

Various structural models for amyloid ? fibrils have been derived from a variety of experimental techniques. However, these models cannot differentiate between the relative position of the two arms of the ? hairpin called the stagger. Amyloid fibrils of various hierarchical levels form left-handed helices composed of ? sheets. However it is unclear if positive, negative and zero staggers all form the macroscopic left-handed helices. To address this issue we have conducted extensive molecular dynamics simulations of amyloid ? sheets of various staggers and shown that only negative staggers lead to the experimentally observed left-handed helices while positive staggers generate the incorrect right-handed helices. In conclusion, this result suggests that the negative staggers are physiologically relevant structure of the amyloid ? fibrils.