Near infrared transillumination imaging of breast cancer with vasoactive inhalation contrast [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.8 Diseases of nervous system and mental disorders
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2010
• Mô tả vật lý: Size: Article No. 295 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261655
• Chủ đề: 1. 60 applied life sciences; 2. Clinical applications; 3. Functional monitoring and imaging; 4. Mammography; 5. Tissue characterization

Tóm tắt

Inhalation of vasoactive gases such as carbon dioxide and oxygen can provide strong changes in tissue hemodynamics. In this report, we present a preliminary clinical study aimed at assessing the feasibility of inhalation-based contrast with near infrared continuous wave transillumination for breast imaging. We describe a method for fitting the transient absorbance that provides the wavelength dependence of the optical pathlength as parametrized by tissue oxygenation and scatter power as well as the differential changes in oxy- and deoxy-hemoglobin. We also present a principal component analysis data reduction technique to assess the dynamic response from the tissue that uses coercion to provide single temporal eigenvalues associated with both oxy- and deoxy-hemoglobin changes.