IC Post-Doctoral Fellowship Abstract and Bio. [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 630.7 Education, research, related topics
• Thông tin xuất bản: Albuquerque, N.M. : Oak Ridge, Tenn. : Sandia National Laboratories. ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2016
• Mô tả vật lý: Size: 1 p. : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 262007
• Chủ đề: 1. 60 applied life sciences

Tóm tắt

Whole cell biosensors (WCBs) utilize an organism?s natural ability to sense and respond to the environment. Through implementation of two different protein engineering methods, I seek to develop a WCB for the detection of important chemical signatures in the environment. I will reengineer the ligand binding profile of proteins known to alter transcription of genes, and I will engineer signal transduction in proteins already known to bind relevant compounds. In both cases, detection of compounds of interest will lead to the production of a measurable fluorescent signal within the organism. These approaches will provide the groundwork for the development of novel chemical sensing technologies that provide a cheap and efficient alternative to traditional methods for detection of compounds.