Tailoring microbes to upgrade lignin [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 668.95 Technology of other organic products
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2020
• Mô tả vật lý: Size: p. 23-29 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 262659
• Chủ đề: 1. 09 biomass fuels; 2. 42 engineering; 3. Aromatic metabolism; 4. Lignin valorization; 5. Renewable feedstock

Tóm tắt

Lignin depolymerization generates a mixture of numerous compounds that are difficult to separate cost-effectively. To address this heterogeneity issue, microbes have been employed to ?biologically funnel? a broad range of compounds present in depolymerized lignin into common central metabolites that can be converted into a single desirable product. Because the composition of depolymerized lignin varies significantly with the type of biomass and the depolymerization method, microbes should be selected and engineered by considering this compositional variation. An ideal microbe must efficiently metabolize all relevant lignin-derived compounds regardless of the compositional variation of feedstocks, but discovering or developing such a perfect microbe is very challenging. Yet, developing multiple tailored microbes to tolerate a given mixture of lignin-derived compounds and to convert most of these into a target product is more practical. This review discusses recent progress towards the development of such microbes for lignin valorization and offers future directions.