The U.S. Department of Energy (DOE) Co-Optima initiative is accelerating the introduction of efficient, clean, affordable, and scalable high-performance fuels and engines. This first-of-its-kind effort is simultaneously tackling fuel and engine research and development (R&D) to maximize light, medium, and heavy-duty vehicle fuel economy and performance, while mapping lower-cost pathways to reduce emissions, leveraging diverse domestic fuel resources, boosting U.S. economic productivity, and enhancing national energy security. Co-Optima brings together DOE's Office of Energy Efficiency & Renewable Energy (EERE), nine national laboratories, 13 universities, and numerous industry and government stakeholders in a collaboration exploring solutions with potential for near-term improvements to the types of fuels and engines found in most vehicles currently on the road, as well as potential for the development of revolutionary new engine technologies.