A comprehensive study has been completed to determine the feasibility of constructing and operating gasification and reforming plants which convert Wyoming fossil resources (coal and natural gas) into the higher value products of power, transportation fuels, and chemical feedstocks, such as ammonia and methanol. Detailed plant designs, simulation models, economic models and well-to-wheel greenhouse gas models were developed, validated by national-level engineering firms, which were used to address the following issues that heretofore have prevented these types of projects from going forward in Wyoming, as much as elsewhere in the United States: 1. Quantification of plant capital and operating expenditures 2. Optimization of plant heat integration 3. Quantification of coal, natural gas, electricity, and water requirements 4. Access to raw materials and markets 5. Requirements for new infrastructure, such as electrical power lines and product pipelines 6. The possible cost-benefit tradeoffs of using natural gas reforming versus coal gasification 7. The extent of labor resources required for plant construction and for permanent operations 8. Options for managing associated CO2 emissions, including capture and uses in enhanced oil recovery and sequestration 9. Options for reducing water requirements such as recovery of the high moisture content in Wyoming coal and use of air coolers rather than cooling towers 10. Permitting requirements 11. Construction, and economic impacts on the local communities This paper will summarize the analysis completed for two major synfuels production pathways, methanol to gasoline and Fischer-Trosph diesel production, using either coal or natural gas as a feedstock.