DNA Replication Controls

• Tác giả: Eishi Noguchi (Ed.)
• Ngôn ngữ: eng
• ISBN-13: 978-3038425687
• Thông tin xuất bản: MDPI - Multidisciplinary Digital Publishing Institute, 2017
• Mô tả vật lý: 1 electronic resource (X, 304 p.)
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 269259
• Chủ đề: 1. DNA helicase; 2. DNA polymerase; 3. DNA replication; 4. replication checkpoint; 5. replication stress

Tóm tắt

The conditions for DNA replication are not ideal, owing to endogenous and exogenous replication stresses that lead to arrest of the replication fork. Arrested forks are among the most serious threats to genomic integrity because they can break or rearrange, leading to genomic instability, which is a hallmark of cancers and aging-related disorders.