Biobetters [electronic resource] : Protein Engineering to Approach the Curative

• Tác giả: Demeule Barthélemy., Amy Rosenberg
• ISBN-13: 978-1493925438
• Ký hiệu phân loại: 615.19 Pharmaceutical chemistry
• Thông tin xuất bản: New York, NY : Springer New York : Imprint: Springer, 2015.
• Mô tả vật lý: XV, 378 p. 50 illus., 22 illus. in color. , online resource.
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 293369
• Chủ đề: 1. Biology-Research; 2. Medicine-Research; 3. Pharmaceutical chemistry; 4. Pharmaceutics; 5. Biomedical Research

Tóm tắt

 Over the last few decades, biopharmaceuticals have transformed many areas of healthcare and have given hope and extended the lives of many patients. Curative treatments, however, remain elusive in most cases. This book describes strategies to develop improved versions of biopharmaceuticals ("biobetters") to bridge the gap between existing therapies and curative therapies. With an aim to stimulate research and development in a wide array of therapeutic areas, diverse topics are covered, including the following: tissue specific targeting of enzyme replacement therapies
  the development of novel protein structures with the potential to improve upon critical attributes of current monoclonal antibodies
  the modification of current monoclonal antibody designs to improve their in vivo stability
  and finally, the economic and regulatory considerations for the development of biobetters.