Computational Modelling of the Human Islet Amyloid Polypeptide [electronic resource]

• Tác giả: Katrine Kirkeby Skeby
• ISBN-13: 978-3319200408
• Ký hiệu phân loại: 615.19 Pharmaceutical chemistry
• Thông tin xuất bản: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Mô tả vật lý: XVI, 118 p. 58 illus., 47 illus. in color. , online resource.
• Bộ sưu tập: Metadata2
• ID: 310086
• Chủ đề: 1. Bioorganic chemistry; 2. Chemistry-Data processing; 3. Medicinal chemistry; 4. Medicinal Chemistry; 5. Computational Chemistry

Tóm tắt

This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins.