Stem Cells and Irradiation

• Tác giả: Alain Chapel
• Ngôn ngữ: eng
• ISBN-13: 978-3036569000
• ISBN-13: 978-3036569017
• ISBN: books978-3-0365-6900-0
• Thông tin xuất bản: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Mô tả vật lý: 1 electronic resource (184 p.)
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 376945
• Chủ đề: 1. human epidermis; 2. keratinocytes; 3. stem cells; 4. Biology, life sciences; 5. Research & information: general

Tóm tắt

The main difficulty of radiotherapy is to destroy cancer cells without depletion of healthy tissue. Stem cells and cancers are tightly interrelated. On one hand, radiosensitivity/radioressistance of cancer stem cells affects the radiocurability of tumors. On the other hand, radiosensitivity is responsible for the stem cell depletion of organs at risk exposed to irradiation. Efficient solide cancer destruction is limited by the preservation of organ homeostasis. For this reason, targeted irradiation is an effective cancer therapy, but damage inflicted to normal tissues surrounding the tumor may cause severe complications. The consequences of stem cell depletion of healthy tissue irradiated are acute and chronic radiation diseases. Research on the radiosensitivity of cancer stem cells and adult stem cells associated with tissue regeneration medicine will bring forth the solution for optimal radiocurability associated with long-term patients' quality of life.