Non-alcoholic Fatty Liver Disease New Insight and Glance Into Disease Pathogenesis

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Tác giả: Ju-Seop Kang

Ngôn ngữ: eng

ISBN-13: 978-1839680908

ISBN-13: 978-1839680915

ISBN-13: 978-1839681028

ISBN: intechopen.100998

Ký hiệu phân loại:

Thông tin xuất bản: IntechOpen 2023

Mô tả vật lý: 1 electronic resource (156 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 377167

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis that develops in the absence of competing for liver disease etiologies such as alcohol consumption, monogenic hereditary conditions, or iatrogenic causes. The pathogenesis of NAFLD is multifactorial and its understanding is still incomplete. Although knowledge of the cellular and molecular mechanisms underlying disease development and progression has grown significantly in recent years, the exact contribution of environmental and genetic factors as well as that of extrahepatic and intrahepatic events in determining the disease phenotype remains ill defined. This book discusses topics highly correlated with NAFLD such as the regulation of iron metabolism, the role of the enzyme heparanase in liver steatosis, transcriptional regulation by ERR and its role in pathogenesis, hepatic lipid homeostasis, therapeutic approaches to NAFLD, and pathogenesis and significance of HDL as a molecular modifier in NAFLD.
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