Multiscale modeling of vascular dynamics of micro- and nano-particles : application to drug delivery system

• Tác giả: Ying Li, Zhiqiang Shen, Huilin Ye
• Ngôn ngữ: eng
• ISBN-13: 978-0750326964
• ISBN-13: 978-0750330190
• ISBN-13: 978-1643277899
• ISBN-13: 978-1643277905
• ISBN-13: 978-1643277929
• Ký hiệu phân loại: 615.7 Pharmacokinetics
• Thông tin xuất bản: Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, 2019
• Mô tả vật lý: 1 online resource (various pagings) : , illustrations (some color).
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 161176
• Chủ đề: 1. Biomechanics; 2. Biomedical materials--Mechanical properties; 3. Blood-vessels; 4. Drug carriers (Pharmacy); 5. Drug targeting; 6. Multiscale modeling; 7. Nanoparticles--Therapeutic use; 8. Biophysics; 9. SCIENCE / Life Sciences / Biophysics; 10. Biocompatible Materials; 11. Blood Vessels--physiology; 12. Drug Carriers; 13. Drug Delivery Systems; 14. Nanoparticles--therapeutic use; 15. Biomechanical Phenomena; 16. Models, Anatomic; 17. Models, Biological

Includes bibliographical references.

Tóm tắt

Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. The current bottlenecks in the optimal design of drug-carrying particles are lack of knowledge about the transport of particles, adhesion on the endothelium wall, and subsequent internalization into diseased cells. To study the transport and adhesion of particles in vasculature, the authors of this book have made great effort to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This text discusses the recent achievements from the establishment of fundamental physical problems to the development of a multiscale model and, finally, large-scale simulations for understanding the transport of particle-based drug carriers in blood flow.