Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms

• Tác giả: Serena Martinelli
• Ngôn ngữ: eng
• ISBN-13: 978-8864535647
• ISBN-13: 978-8864535654
• ISBN-13: 978-8892731684
• Ký hiệu phân loại: 616 Diseases
• Thông tin xuất bản: Florence : Firenze University Press, 2017
• Mô tả vật lý: 1 electronic resource (80 p.)
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 241338
• Chủ đề: 1. Biochemistry; 2. Biology, life sciences; 3. Molecular biology; 4. Pre-clinical medicine: basic sciences; 5. Pharmacy / dispensing

Tóm tắt

A gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). Enhanced activation of other downstream pathways including the PI3K/mTOR pathway has been documented as well. In this study we evaluated the effects of JAK1/2 inhibitors, alone and in combination with mTOR, with a dual mTOR/PI3K inhibitor and with a pan PI3K inhibitor in in-vitro and in-vivo MPN models. Our findings of strong synergy between the JAK2 inhibitors and mTOR/PI3K inhibitor suggested that we might be able to administer these drugs at lower concentrations than when the drugs are used individually. This provides a framework for combination trials using compounds in patients with myeloproliferative neoplasms