The green-routing strategy instructing a vehicle to select a fuel-efficient route benefits the current transportation system with fuel-saving opportunities. This paper introduces a navigation application programming interface (API), route fuel-saving evaluation framework for estimating fuel advantages of alternative API routes based on large-scale, real-world travel data for conventional vehicles (CVs) and hybrid electric vehicles (HEVs). Navigation APIs, such as Google Directions API, integrate traffic conditions and provide feasible alternative routes for origin-destination pairs. This paper develops two link-based fuel-consumption models stratified by link-level speed, road grade, and functional class (local/non-local), one for CVs and the other for HEVs. The link-based fuel-consumption models are built by assigning travel from many global positioning system driving traces to the links in TomTom MultiNet and road grade data from the U.S. Geological Survey elevation data set. Fuel consumption on a link is computed by the proposed model. This paper envisions two kinds of applications: (1) identifying alternate routes that save fuel, and (2) quantifying the potential fuel savings for large amounts of travel. An experiment based on a large-scale California Household Travel Survey global positioning system trajectory data set is conducted. The fuel consumption and savings of CVs and HEVs are investigated. At the same time, the trade-off between fuel saving and travel time due to choosing different routes is also examined for both powertrains.