This book explores how culture and tradition have impacted the tendency for African women to opt for entrepreneurship. The first section presents literature on the concept of entrepreneurship and introduces traditional African women entrepreneurs-the first-generation, culture-driven entrepreneurs, driven by the need to alleviate poverty within the family. The second section covers the modern, second-generation entrepreneurs driven by such forces as education, globalization, and technology. Further, the author assesses the regional perspectives on entrepreneurship and explores the entrepreneurial ecosystems to determine their relevance to the development of entrepreneurial spirit in Africa and among women in particular. This book expands on knowledge about the role that women play in the socio-economic development of the African continent. Chi Anyansi-Archibong is Professor Emerita at North Carolina A&T, USA. She is Past President of the North American Case Research Association (NACRA) and Founder of Southeast Case Research Association.