Bioinformatics Techniques for Drug Discovery [electronic resource] : Applications for Complex Diseases

• Tác giả: Shiv Bharadwaj, Ravi Chaudhary, Aman Chandra Kaushik, Ajay Kumar, Shakti Sahi
• ISBN-13: 978-3319757322
• Ký hiệu phân loại: 570.113 Life sciences Biology
• Thông tin xuất bản: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Mô tả vật lý: XI, 57 p. 8 illus., 7 illus. in color. , online resource.
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 330271
• Chủ đề: 1. Bioinformatics; 2. Pharmacology; 3. Computational and Systems Biology

Tóm tắt

The application of bioinformatics approaches in drug design involves an interdisciplinary array of sophisticated techniques and software tools to elucidate hidden or complex biological data. This work reviews the latest bioinformatics approaches used for drug discovery. The text covers ligand-based and structure-based approaches for computer-aided drug design, 3D pharmacophore modeling, molecular dynamics simulation, the thermodynamics of ligand−receptor and ligand−enzyme association, thermodynamic characterization and optimization, and techniques for computational genomics and proteomics.